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                碳納米管對血液中重要蛋白的影響
                來源: | 作者: | 發布時間:2014-4-15 18:21:34

                碳納米管對血液中重要蛋白的影響
                封如,焦延鵬,周長忍
                基金項目:教育部博士點新教師基金資助項目(20094401120006);廣東省科優秀博士論文項目(sybzzxm201034)
                作者簡介:封如(1986-),女,在讀研究生,主要研究方向:生物材料
                通信聯系人:焦延鵬(1975-),男,研究員,主要研究方向:生物材料.

                (暨南大學材料科學與工程系)
                摘要:碳米管材料近年來備受關注,廣泛應用于藥物傳導、核酸傳導、光學治療和光聲分子成像等領域。碳米管主要是通過血液循環系統進入人體,會影響多種血液組分的生物功能。血清蛋白、γ-球蛋白和纖維蛋白原是人體血液中的三種主要蛋白,納米管材料進入血液后,會不可避免地與這三種蛋白相互作用,影響這些蛋白的結構與功能。為了實現納米管的臨床應用,有必要研究它們與這些血液蛋白之間的相互作用機理。本文研究了單壁碳納米管在不同濃度(0.001-0.5mg/mL)下對血清蛋白、γ-球蛋白和纖維蛋白原連續作用2 小時后,使用了紫外分光光譜、熒光光譜和圓二色譜分析了蛋白結構的變化。實驗結果表明,碳納米管對蛋白的影響與投入濃度是正相關的;在某一低濃度范圍(≤0.05mg/mL)內,納米管不會對血清蛋白、γ-球蛋白、纖維蛋白原的結構和功能產生影響。該實驗結果為碳米管材料在某一濃度范圍內的臨床應用提供了有效信息。
                關鍵詞:碳納米管;血液蛋白;血液相容性;
                中圖分類號:R944.9
                Effect of carbon nanotube on the structure of major proteins in blood
                Feng Ru, Jiao Yanpeng, Zhou Changren
                (Department of Materials Science and Engineering, Jinan University, Guang Zhou 510632)
                Abstract: Nanotube materials are recently receiving considerable attention in drug delivery,nucleic acid delivery, biomaterials therapy and photo acoustic molecular bio-imaging. For in vivo application, nanotubes will enter blood circulation and interact with various blood components and  to affect their bio-functions. Serum albumin, γ-Globulin and Fibrinogen are three major proteins in human blood. The interaction of nanotubes with these proteins are unavoidable, affecting the structure and fuction of the proteins and even the whole organism. So this effect should be clearly elucidated at cellular and molecular levels. In this study, the effect of Single-Wall Carbon Nanotubes (CNT) on Bovine Serum Albumin (BSA), γ -Globulin and Fibrinogen were 30 investigated. The proteins were exposed to nanotubes for 2 hours at different concentrations (0.001-0.5mg/mL). The results showed that the effect on proteins was positively correlated with the exposed nanotubes' concentration. When the concentration was less than 0.05mg/mL, nanotubes led to no significant negative inpact on the structure and fuction of the proteins. The data provide useful information for further clinical applications of nanotube materials.
                Key words: Carbon nanotubes; Blood proteins; Hemocompatibility

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