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                MxA基因多態性與慢性乙肝患者IFNα應答情況關聯研究
                來源: | 作者: | 發布時間:2014-4-15 15:36:26

                MxA基因多態性與慢性乙肝患者IFNα應答情況關聯研究
                時韋美1,伍曉盼1,朱席琳1,李卓2,李輝3,劉英1
                基金項目:高等學校博士學科點專項科研基金(20101106110021) 作者簡介:時韋美(1990-),女,碩士,多基因疾病遺傳易感性和藥物遺傳學研究 通信聯系人:劉英(1961-),女,研究員,多基因疾病遺傳易感性和藥物遺傳學研究;單基因疾病致病基因的定位克隆.

                (1. 北京協和醫學院基礎學院生物化學與分子生物學系,北京 100005;2. 首都醫科大學附屬北京佑安醫院,北京 100005; 3. 北京協和醫學院基礎學院流行病學系,北京 100005)
                摘要:目的:探究MxA基因14個SNP位點(rs2838035,rs17000959,rs467639,rs7509964,rs13050928,rs458255,rs469073,rs469083,rs1050008,rs2075807,rs2238720,rs1557372,rs1557370,rs8133682)與慢性乙肝患者干擾素α個體療效之間是否存在相關性。方法:收集北京佑安醫院就診接受IFNα治療的254例(男性210例,女性44例)中國漢族原發性慢性乙肝患者的血樣及臨床資料,提取DNA,并進行基因分型。結果:MxA基因rs469083等位基因頻率及基因型分布在干擾素α應答組與無應答組間有統計學意義(P分別為0.05和0.005,OR=1.50,95%CI=0.99-2.27)。 單倍型T-T-A-A-A-G-G-C-G-G-G-C-G-C單倍型在應答組高于無應答組(12.4% vs. 7.4%,P=0.07,OR=1.95,95%CI=0.93-4.08)。結論:MxA基因rs469083位點與慢性乙肝患者干擾素α個體療效相關,攜帶單倍型T-T-A-A-A-G-G-C-G-G-G-C-G-C的個體可能更易獲得干擾素α應答。
                關鍵詞:慢性乙肝;MxA;SNP;干擾素α
                中圖分類號:R394.3 20
                MxA gene polymorphisms with response to IFNα in chronic hepatitis B patients
                SHI Weimei1, WU Xiaopan1, ZHU Xilin1, LI Zhuo2, LI Hui3, LIU Ying1
                (1. National Laboratory of Medical Molecular Biology,Institute of Basic Medical 25 Sciendes,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005; 2. Department of Infectious Disease,Affiliated Youan University of Medical Science,Beijing 100005; 3. Department of Epidemiology,Institute of Basic Medical Sciendes,Chinese Academy of Medical 30 Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005)
                Abstract: Objective: We aimed to evaluate the correlation of 14 SNPs (rs2838035, rs17000959, rs467639, rs7509964, rs13050928, rs458255, rs469073, rs469083, rs1050008, rs2075807, rs2238720, rs1557372, rs1557370, rs8133682) in MxA gene with the individual efficacy of IFNα therapy in chronic hepatitis B patients. Methods: We collected the peripheral blood samples and clinical characteristics of 254 chronic hepatitis B patients received IFNα therapy(male 210,female 44). Then genomic DNA was extracted and the genotyping of MxA 14 SNPs was performed. Results: There was significant difference with the SNP rs469083 in MxA and the response state of IFNα, in both the single allele frequency and genotype distribution (p is respectively 0.05 and 0.005, OR=1.50, 95%CI=0.99-2.27). The frequency of the T-T-A-A-A-G-G-C-G-G-G-C-G-C haplotype in the response group was higher than that in the non-response group(12.4% vs. 7.4%, P=0.07, OR=1.95, 95%CI=0.93-4.08). Conclusions: The present nested case-control study indicated that the SNP rs469083 in MxA was significantly associated with the individual efficacy of IFNα therapy in chronic hepatitis B patients. The T-T-A-A-A-G-G-C-G-G-G-C-G-C haplotype carriers may be more easier to achieve IFNα response.

                Key words: chronic hepatitis B; MxA; SNP; IFNα

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