<form id="hdxdf"></form>

                <address id="hdxdf"><nobr id="hdxdf"><meter id="hdxdf"></meter></nobr></address>
                當前位置:首頁 > 資訊信息 > 新聞動態 > 詳細信息
                ICGC公布逾1萬個癌癥基因組數據
                來源:ICGC公布逾1萬個癌癥基因組數據 | 作者: | 發布時間:2014-10-30 8:40:56

                國際癌癥基因組聯盟(International Cancer Genome Consortium,簡稱"ICGC")近日向科研界公布了超過1萬個癌癥基因組的數據。這些數據能更好地幫助全世界的癌癥研究者從基因方面了解癌癥,加快對癌癥的研究并幫助更多癌癥靶向治療的發展。

                安大略癌癥研究所所長兼科學總監、國際癌癥基因組聯盟創始人之一TomHudson醫生說:"GLOBOCAN的數據顯示,2012年全球約有1400萬人確診患上癌癥,820萬人死于該疾病。預計至2025年,由于人口增加和老齡化,每年將新增超過2000萬癌癥病例。眼下癌癥診治急需新的途徑。如果能更好地從基因組來了解癌癥,那么將更有利于癌癥的預防和控制,這是2014年世界癌癥報告所傳達的關鍵信息。"

                2014年世界癌癥報告于2014年2月3日,即世界癌癥日前一天在倫敦發表。該報告每五年發表一次,向癌癥領域之外的決策者和醫療專業人員提供有關信息,同時也旨在向癌癥專家提供有關癌癥研究和控制方面的最新和重大進展的信息。

                Hudson為今年的報告撰寫了一個章節,解釋為何癌癥可被視為基因疾病以及基因組突變如何加速腫瘤生長。他同時也闡明在基因多樣性、環境以及飲食等因素的影響下,基因突變的情況在不同人群中也有不同。這些多樣性形成了現時各種癌癥類型和亞型。這一章還提到ICGC正在對2.5萬多個腫瘤樣本進行測序,以生成與50種癌癥相關的癌癥基因突變目錄。

                安大略研究及創新廳廳長RezaMoridi談到:"安大略政府投入的資源鞏固了我們在癌癥研究領域的領導地位,吸引全球頂尖的研究人才到來,他們都為改善安大略乃至全世界人民的生活做出努力。安大略癌癥研究所促進科研人員的合作,推動重要研究的進展,把實驗室的發現應用于實際治療。這不僅能幫助到患者,還將為安大略的創新經濟做出顯著貢獻。"

                安大略癌癥研究所的研究人員正進行一項大型的癌癥基因研究,作為ICGC的全球癌癥基因組計劃之一部分。ICGC的全球研究已取得幾項重大發現,包括癌癥的生成過程及基因的多項發現。這些研究表明基因突變率會因為癌癥類型的不同而出現1000種變化,另外癌癥的生成是多種獨特的突變模式的綜合結果,部分癌癥是與一些已知的突變原有關,例如香煙煙霧與紫外線。

                身為安大略癌癥研究所信息與生物計算系主任,同時也是位于加拿大多倫多的ICGC數據協調中心的主任LincolnStein博士說:"癌癥極其復雜,即使是有著相似特性的腫瘤,在不同患者身上都可以出現明顯的差異。隨著時間推移和治療的進展,同一類腫瘤也會出現明顯的變異。對于癌癥我們仍有許多東西要學,但是我們已經步入正確的軌道,在了解癌癥方面取得了重大的進展。"

                關于國際癌癥基因組聯盟

                國際癌癥基因組聯盟(ICGC)由來自世界各地的研究所組成,致力于快速暢通地為外界提供信息。ICGC的門戶網站www.icgc.org中載有逾1萬腫瘤相關的癌癥基因組信息。ICGC每一個成員項目都對至少一種癌癥的變種和亞種的基因變化進行全方位、高解析度研究,這些研究都以數據收集和分析的通用標準為依歸。

                ICGC現時已獲得來自亞洲、澳洲、歐洲和北美的撥款機構向17個行政轄區的71個項目團隊提供的撥款,以用于超過2.5萬項腫瘤基因組的研究。現已得到資助的項目涉及以下的腫瘤研究:膽道、膀胱、血液、骨、大腦、乳腺、子宮頸、結腸、眼、頭頸、腎、肝、肺、鼻咽、口腔、卵巢、胰腺、前列腺、直腸、皮膚、軟組織、胃、甲狀腺以及子宮。下列國家的ICGC成員就下列腫瘤基因組進行的研究信息,現在可于ICGC官網的數據協調中心分頁獲取︰澳大利亞(卵巢與胰腺癌)、加拿大(胰腺與前列腺癌)、中國(腎癌)、法國(肝與腎癌)、德國(血癌、大腦與前列腺癌)、印度(口腔癌)、日本(肝癌)、沙特阿拉伯(甲狀腺癌)、西班牙(血癌)、英國(血癌、骨、乳腺以及食道癌)以及美國(膀胱、血、大腦、乳腺、子宮頸、結腸、頭頸、腎、肝、肺、卵巢、胰腺、前列腺、直腸、皮膚、胃、甲狀腺與子宮癌)。

                《世界復合醫學》

                苏宁彩票 www.180092.com | 1017.com | www.cp9518.com | 068789.com | www.6600ra8.com | 55331cc.com | www.68365q.com | 28288u.com | www.43818d.com | 4637700.com | www.401280.com | www.171717.cc | q61788.com | www.026688.com | qjdy004.com | www.916570.com | www.wnsr66.com | 915610.com | www.m7764.com | cc3336.com | www.41518s.com | www.7893w4.com | www.50052v.com | www.qmc0044.com | eee444000.com | www.6939b.com | www.kima88.com | www.175902.com | www.948.com | 4018c.com | www.5091b.com | www.550290.com | vv1331.com | www.704905.com | gg5144.com | www.633813.com | www.889029.com | ca5033.com | www.js02349.com | www.glc11.com | 3650755.com | www.38775qq.com | 79964g.com | www.78949u.com | www.4972o.com | 234901.com | www.621481.com | www.caipiao88b.com | 70118z.com | www.65707o.com | www.9464005.com | www.737.am | 8827b.com | www.sha2244.com | 23800v.com | ditu.so.com | www.735585.com | www.hg2877.tv | 445199.com | www.4923n.com | www.ty971.com | 18438m.com | ope88.com | www.qiji111.com | www.7494455.com | 1434p.com | www.71399w.com | www.boma0157.com | xs9411.com | www.35155h.com | www.133242.com | 00773c.com | www.799243.com | www.g456x.com | heji271.com | hd61788.com | www.9464gg.com | www.xjs8891.com | 78666x.com | www.761996.com | www.00778x.com | jjjj004.com | 2844z.com | www.50052s.com | www.939168.com | 2127jj.com | www.50051i.com | www.7249s.com | www.29645.com | ww3336.com | www.346977.com | www.h1432.com | www.g83138.com | 40033ttt.com | www.193161.com | www.418587.com | www.558337.com | 61652a.com | www.025738.com | www.cb900.cc | www.945suncity.com | p5555.com | 022573.com | www.646959.com | 6830q.com | 88304k.com | www.36788f.com | www.8967o.com | 33115oo.com | 781520.com | www.683717.com | 2247gg.com | 403237.com | www.9646o.com | www.282866.com | hhh8827.com | 5281999.c0m | www.997345.com | www.7hg6668.com | www.77537e.com | www.348377.com | www.win1231.com | www.10601.com | fc9558.com | 28288nn.com | www.cb7588.com | www.7334f.com | www.pj9086.com | 3656uu.com | 099568.com | www.877719.com | www.8080999g.com | www.467233.com | 500000311.com | 11555156.com | www.196909.com | www.50054t.com | www.844218.com | www.0860s.com | 26444y.com | 4066h.com | 20132019.com | www.657832.com | www.81678l.com | www.99113c.com | www.rrrr0076.com | www.yh6996.com | 8522eeee.com | 444000rrr.com | www.548611.com | www.9646h.com | www.06820k.com | www.6y7y.net | www.7025a.com | 2844j.com | 5360w.com | 6175kk.com | bogou800.vip | www.394577.com | www.2350f.com | www.9187l.com | www.123377.com | www.pj0567.com | uc07.cc | 0471sands.com | yhzhejiang.vip | www.401282.com | www.hm5688.com | www.3846ee.com | www.2011.vip | www.vip36059.com | www.560404.com | www.56733v.com | 4379o.com | 32355qq.com | 1213ooo.com | r86811.com | www.zfcp1.com | www.yun879.com | www.07679d.com | www.4972o.com | www.hj809.com | www.773333.com | www.2078k.com | 272k.net | 500000777.com | 3522mm.com | xhtd12345.com | 3473n.com | 496dd.com | www.137518.com | www.631027.com | www.ch8456.com | www.5522d.cc | www.750877.com | www.7240j.com | www.44118m.com | www.qmc0011.com | www.28758c.com | www.xb0029.com | www.my1069.net | www.1348-4.com | www.df4566.com | www.68666k.com | 3258q.com | pp56988.com | 11683333.com | pj38pj38.com | 2698l.com | 6040055.com | 8036ll.com | 3121b.com | 915590.com | 2934.com | www.1114xj.com | 0600s.cc | www.4763118.com | 88119193.com | www.yd555888.com | www.774426.com | www.20088hg.com | 8036gg.com | 4638855.com | 9030b.com | 73999u.com | 3122o.com | 1274kc.com | www.y613377.com | www.4688111.com | www.4853c.com | www.155a56.com | www.10133c.com | www.807881.com | www.452222.com | www.552567.com | www.566652.com | www.00772i.com | www.g32939.com | www.5446xx.com | www.9941331.com | www.js89j.vip | www.tyc88666.com | www.033.la | www.5854j.cc | www.631012.com | www.475711.com | www.338017.com | 1775z.com | 2851l.com | 11117893.com | bet22222.com | 6112jj.com | bet99939.com | 2709a.com | 7008037.com | www.yh8894.com | www.d27229.com | www.2566h5.com | www.153995.com | www.c5c77.com | www.32031r.com | www.430188.com | www.21202l.com | www.530 | www.914908.com | zyxxd.com | v3144.com | 2649ss.com | 54140011.com | 58-mm.com | www.ag3131g.com | www.444171.com | www.633756.com | www.hg0297.com | www.66ckb.com | www.308126.com | 365.sb | 3178dd.com | 365vip800.cc | www.8694t.com | www.77msctyc.com | www.40598.com | www.4323s.com | www.009hy.cc | 78119988.com | 4136k.com | 56988jj.com | www.wns8833.com | www.61345.cc | www.99788n.com | www.901375.com | 7792o.com | 6002v.com | 1077eee.com | www.hg00868.com | www.33678ss.com | www.113744.com | www.755213.com | 5004v.com | hhvip666.com | www.vns3n3.com | www.601066.com | www.908296.com | www.786682.com | js88830.com | 00773p.com | www.4972hh.com | www.ee55826.com | www.80767g.com | www.348477.com | 88904040.com | t222c.com | www.zr244.com | www.89677j.com | www.53536.cc | www.55228a.com | t1458.com | 2003.com | www.js406.com | www.pj55712.com | www.982799.com | 5906FF.com | y68147.com | www.hg8102.com | www.99552ss.com | www.987423.com | 3734.com | 3245b.com | www.552318.com | www.bet73v.com | 20188s.com | v4212.com | www.20161122.com | www.299770.com | www.444627.com | 5448099.com | www.25673.com | www.5099rr.com | www.1368u.cc | 22qq8332.com | 1259g.com | www.rycp047.com | www.6832m.com | 3122qq.com | 7720m.com | www.57798d.com | www.xpj13666.com | www.137165.com | 3807q.com | www.hg130.com | www.960023.com | www.755216.com | 2844f.com | www.9785999.com | www.11521.com | www.517411.com | jj4119.com | www.xw2200.com | www.68993263.com | www.26878a.com | p8381.com | www.yao656.com | www.54400w.com | 5003j.com | www.js736736.com | www.4196a.com | www.355240.com | 3435r.com | www.006087.com | www.ampj3433.com | 5855ll.com | www.ylg5999.com | www.9997028.com | www.238500.com | 507dh.com | www.yy6656.com | www.916177.com | 272ee.net | 6403i.com | www.sands2008.com | www.579199.com | 3807ll.com | www.hg8265.com | www.89894m.com | huangma21.com | www.x7044.com | www.win1235.com | hy9996.com | www.xpj5555.cc | www.9464002.com | man152.com | 5589a.com | www.69567t.com | 2349001.com | 88665004.com | www.i63568.com | hhh5144.com | t365e.com | www.14168f.com | 99662016.com | www.39695c.com | www.3978h.com | 684526.com | www.4amhg.com | www.5091s.com | 11113885.com | www.55526d.com | www.451956.com | 2677ttt.com | www.4521i.com | 20778866.com | www.333133r.com | www.50024k.com | 4912d.com | www.xg611.com | www.652918.com | xhtd.com | www.ylg292.com | www.g0041.com | www.10380.cc | 4955f.com | www.50999z.com | www.003561.com | www.8js189.com | www.js18683.com | 28758y.com | www.3131666.com | www.362803.com | www.772345.com | www.1754d.com | 5004rrr.com | 915620.com | www.ejylc12.com | 9103kk.com | www.jnh885.com | www.813230.com | 86811bb.com | www.cp505.com | www.226705.com | 22296an.com | www.83033p.com | blm877.com | www.55060y.com | www.35918o.com | www.hg9689.com | www.1111y.cc | 4323t.com | www.234.pw | 4165r.com | www.a81m.cc | 256777v.com | www.777444b.com | www.hy5455.com | zhcp66.com | www.3398766.com | 999p1.cc | www.4078d.com | 1168x.com | www.39666.com | www.77801i.com | www.402j2.com | www.854980.com | 02w66.vip | www.9356m.com | 99567s.com | www.185647.com | 53358f.com | www.087u.com | 35222uu.com | www.99552bb.com | 23478.com | www.38138o.com | 33335002.com | www.8883hj.com | 9484H.com | www.938g.cc | 6423l.com | www.e4042.com | y1429.com | www.818515.com | vs9777.com | www.81306b.com | 3189ee.com | www.849958.com | 5003com | www.8804jj.com | www.050955.com | www.026319.com | www.kj310.cc | 1389qq.com | www.18123.com | 01885z.com | www.gg55826.com | zhcp83.com | www.4996dq.com | 08778t.com | www.838957.com | 4541l.com | www.093738.com | 50067b.com | www.800938.com | 500000439.com | www.90989.com | 7141ee.com | www.61456.com | 3568n.com | www.n3065.com | df8w.com | www.9187x.com | 53059.com | www.78949l.com | 3438w.com | www.849129.com | www.333133r.com | 33sb.com | www.55526f.com | 97297u.com | www.ba502.com | 53059.com | www.81520.com | www.ylg89.com | www.293788.com | www.363123.com | 3565.com | www.1429g5.com | 40033mmm.com | www.51331f.com | www.033033a.com | www.505170.com | www.778849.com | 1137.com | www.11599068.com | 2458.com | www.584611.com | www.bm9998.com | js58881.com | www.5719b.com | dzc07.com | www.810877.com | www.23373333.com | 7249g.com | www.32031e.com | 23800i.com | www.673266.com | www.betqam.com | z83377.com | www.550022.com | 500000349.com | www.371411.com | www.078999.com | bet577.com | www.60007y.com | www.7610679.com | 515165.com | www.69567k.com | 0747jj.com | www.205880.com | www.twcp05.com | 4289d.com | www.qucw2.com | www.blr795.com | 5856j.com | www.790711.com | www.pjbet888.com | 2595d.com | www.087v.com | www.a8a8567.com | 8011.cc | www.y6098.com | 3938.com | sss5701.com | www.6880dd.com | 5077888.com | 98955d.com | www.ba302.com | 1654jj.com | nn2649.com | www.0282.com | www.133494.com | zhcp88.com | www.drf1.net | www.h7788c.com | ff555n.com | www.76520c.com | www.hg50668.com | 256777gcom | www.5854e.cc | www.5994.com | 3950t.com | www.755864.com | www.ggz.99233z.com | qjdy019.com | www.444219.com | www.00773k.com | 2649dd.com | 1468ddd.com | www.91779r.com | www.45601.com | 32212b.com | www.bet73y.com | www.hg55328.com | 0201kk.com | www.998786.com | www.983888b.com | 3245999.com | www.918356.com | www.lfcp097.com | p888rr.com | www.54400u.com | www.7036kk.com | www.yh8214.com | 20775599.com | www.5688y.cc | www.50000.com | 822930.com | 0683i.com | www.8828229.com | www.ao299.com | 3648.com | www.hcw018.com | www.86339p.com | www.yh66855.com | aaa8996.com | www.666407.com | www.4196b.com | www.ww.t7888.com | 58222u.com | www.547377.com | www.js38678.com | www.js106.cc | am775.cc | www.51515e.com | www.hg77033.com | www.hg5100.com | 2127app.com | 3190.com | www.66621q.com | www.63328.cc | 2776n.com | 51529.com | www.846662.com | www.2544b2.com | www.caipiao045.com | 3534i.com | 20188d.com | www.83033d.com | www.bai5544.com | 589669.com | 36989f.com | www.529121.com | www.0612j.com | www.22244066.com | 08159w.com | s00351.com | www.yi636.com | www.w948w.com | www.86611u.com | 1654g.com | www.212632.com | www.vn888345.cc | www.7817g.vip | www.81866y.com | 22668448.com | drcp444.com | www.26878d.com | www.8850w4.com | www.yh6679.com | 7788332.com | 3552i.com | www.725422.com | www.35996.com | www.suncity3.com | 1wns.com | xy55355.com | feicai0471.com | www.gczj7.com | www.3w25.com | www.18997.com | www.chun1983.com | 6487iii.com | 91019k.com | www.738126.com | www.764169.com | www.1759.com | www.32666s.com | 3078w.com | 7508u.com | w0000.vip | www.99fzc.com | www.69488.com | www.msc-88msc.com | www.3657f.com | 6261ee.com | 11773885.com | 9694j.com | www.855085.com | www.yh08.com | www.4996sd.com | www.hg7842.com | www.tbb001.com | w8381.com | 4022xx.com | 3379pp.com | www.794918.com | www.3978r.com | www.3116r.com | www.789025.com | www.lb0044.com | 56988j.vip | hm0282.com | 78116655.com | www.50732v.com | www.998632.com | www.0601e.com | www.509530.com | www.770777.com | www.caipiao045.com | 3834504.com | 2jsxxx.com | 7003tt.com | xpj8930.com | www.364616.com | www.gai20.com | www.89777t.com | www.006785.com | www.z4042.com | www.5028hg.com | www.ks081.com | 3379ll.com | js345b.com | 2072.com | 66648z.com | 5478xl.com | www.424770.com | www.2350z.com | www.4323m.com | www.12345604.cc | www.9737qq.com | www.a11133.com | www.vns2016.com | www.hg9946.com | 5369s.com | 55qq8332.com | 50099g.com | 3416p.com | 53059.vip | 386kzk.com | 28288n.com | am2017111.com | www.330732.com | www.848255.com | www.wo41.com | www.29277w.com | www.88888.mx | www.9996.com | www.r999997.com | www.3116e.com | www.7415ss.com | www.888c31.com | www.v1186.com | www.65175.com | www.b5233.com | www.21365xx.com | www.8124v.com | www.ylg777555.com | dh4546.com | wns940.com | 22338332.com | 3379bb.com | 556888.com | ying58.xyz | 50067i.com | 88851j.com | 3685c.com | wnsr8817.com | dh7022.com | wnsr8811.com | 33382pp.com | 808cp.org | 26668u.com | j1486.com | 2096n.com | 7720i.com | c63.cc | 3009e.com | 893620.com | 7141yy.com | 6a222.com | 1665bb.com | www.68666n.com | www.379568.com | www.365109e.com | www.55268ss.com | www.pj3098.com | www.hg2020y.com | www.345188.com | www.654777.com | www.303365.com | www.35252q.com | www.79500h.com | www.xpj2010.com | www.pjgw99.com | www.js68678.com | www.750041.com | www.954321w.com | www.88266x.com | www.50024n.com | www.99jtc.com | www.713799.com | www.498166.com | www.36787i.com | 8901d.com | ii2649.com | 9697444.com | f666.org | 99567c.com | 009900.com | www.dhy2929.com | www.88837z.com | www.508555.com | www.4853.com | www.313965.com | www.amjs3456.com | www.73166c.com | www.c1393.com | www.390685.com | amhj.cc | c63awgd8.com | 7508s.com | 28288rr.com | www.bh22678.com | www.amxhtd8.com | www.360049.com | www.11tyc.com | www.877636.com | www.80767b.com | www.976381.com | www.232651.com | 97886699.cc | 8898222.com | 00773rr.com | 1483hh.com | www.sun7766.com | www.mgdc46.com | www.bwinyz40.com | www.3a331.com | www.1999ac.com | www.385626.com | 5002z.com | 3522ii.com | mg437700.com | www.63877t.com | www.734555.com | www.bwinyz39.com | www.081234.com | www.hr1888.com | www.61655o.com | 4880c.com | 54146699.com | 31325l.com | www.191949.com | www.8850w5.com | www.yh68073.com | www.c757.vip | 30174455.com | 0698v.com | pj886.com | www.zsdl9.com | www.178659.com | www.095928.com | www.535666a.com | 8988444.com | 9484F.com | 5589t.com | www.11012.app | www.dzj0110.com | www.6613644.com | www.652561.com | aa3336.com | js345b.com | www.7720h.com | www.beb111.org | www.ff4625.com | www.w935.com | 11683344.com | 4303go.com | www.86611n.com | www.5588212.com | www.r99999.com | www.qucp9.com | 7737.com | t21148.com | www.3888bet.com | www.3533msc.com | www.165888.com | www.657505.com | 86811nn.com | 7742m.com | www.9680app.com | www.10999y.com | www.8039h.com | 701679.com | oo8159.cc | www.vns8891.com | www.50999g.com | www.52303h.com | 45637v.com | 8159x.cc | www.bet36578.com | www.w32939.com | www.15199.cc | judingbo9.com | 4340q.com | www.1829q.com | www.5886nn.com | www.890413.com | 9339999s.com | mgm3242q.com | www.pj3377.com | www.68993269.com | www.178591.com | 30524.com | www.boma0111.com | www.766159.com | www.912453.com | 91019f.net | hpzx88.com | www.79500i.com | www.9818i.cc | 3122kk.com | 0747kk.com | www.899111.com | www.15365.com | 2019ii.cc | 44oo8332.com | www.533589.com | www.bet73z.com | 6446zz.com | 99992007.com | www.40789b.com | www.95222w.com | 3844cc.com | 7454jj.com | www.xj666s.com | www.26163d.com | 1669c.com | 55335004.com | www.8850w7.com | www.980273.com | 68742.com | www.yh8220.com | www.33678ww.com | www.376817.com | ddd3405.com | www.4719cc.com | www.js00558.com | 2506q.com | hb8331.com | www.5049q.com | www.0qxc.com | 08159r.com | www.2090933.com | www.3846c.com | www.33588v.com | hubet555.com | www.158cai.com | www.799666aa.com | 1294n.com | www.4645555.com | www.7714r.com | t8159.cc | www.ylhg6868.com | www.73990l.com | www.183799.com | 6xh.vip | www.2945.com | www.935257.com | yth008.net | www.hg0782.com | www.65707x.com | 28824c.com | www.809990.com | www.1466y.com | 30006m.com | www.sjs14.com | www.3w27.com | sss5701.com | 058757.com | www.40288x.com | 86wns88.com | feicai0555.com | www.55070i.com | www.303853.com | 9694x.com | www.8473r.com | www.324177.com | 35cc.vip | www.0662777.com | www.431770.com | tz397.com | www.hs6666.com | www.010956.com | hd8332.com | www.704902.com | 23800p.com | www.ylg292.com | www.111128.com | 1389e.com | www.00618v.com | www.53900k.com | alpk11.com | www.xg289.net | www.zg16.com | 57157d.com | www.jinbocp.com | www.328477.com | 2649b.com | www.7036kk.com | 115504.com | www.55268ll.com | www.00840r.com | hgvipvip3.com | www.jjjj44444.com | www.djcp001.com | 55p88.cc | www.97994c.com | dejinbet.com | www.05125c.com | www.5091o.com | 35222a.com | www.88166e.com | ww3822.com | www.hg4111.com | www.88266w.com | pj3508.com | www.xj666o.com | www.259989.com | 7335z.com | www.dy506.com | vip145b.com | www.7agcpw.com | www.022193.com | www.jsh110.com | www.77801t.com | b45638.com | www.615073.com | 7605z.com | www.39695.com | www.8667f.com | 66300vip40.com | www.316088.com | 00773n.com | www.61515g.com | www.721709.com | zhcpmm.com | www.188jinbaobo.com | 30175555.com | www.q456x.com | 7196g.com | www.7111z.com | www.588088a.com | 2846p.com | www.868229.com | 5856aaa.com | www.pj5060.com | 19880.com | www.303365.com | 9539h.com | www.x30226.com | www.975961.com | ii5443.com | www.29496a.com | 173203.com | www.213981.com | 2998v.com | www.79500r.com | 3202f.com | www.159kj.com | 22mm8332.com | www.y18kk.com |