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                清華癌癥研究取得突破:人類有望“餓死”癌細胞
                來源:清華癌癥研究取得突破:人類有望“餓死”癌細胞 | 作者: | 發布時間:2014-10-30 8:38:19

                清華大學宣布:該校醫學院顏寧教授研究組在世界上首次解析了人源葡萄糖轉運蛋白GLUT1的晶體結構,初步揭示了它的工作機制以及相關疾病的致病機理,在人類攻克癌癥、糖尿病等重大疾病的探索道路上邁出了極為重要的一步。未來,人類有望“餓死”癌細胞。

                昨天的英國《自然》雜志以長文的形式正式刊發了這一成果。據介紹,葡萄糖是地球上各種生物最重要、最基本的能量來源,也是人腦和神經系統最主要的供能物質。據估算,大腦平均每天消耗約120克葡萄糖,占人體葡萄糖總消耗量的一半以上。葡萄糖代謝的第一步就是進入細胞,但親水的葡萄糖溶于水,而疏水的細胞膜就像一層油,因此,葡萄糖自身無法穿過細胞膜進入到細胞內發揮作用,必須依靠轉運蛋白這個“運輸機器”來完成。葡萄糖轉運蛋白鑲嵌于細胞膜上,如同在疏水的細胞膜上開了一扇一扇的門,能夠將葡萄糖從細胞外轉運到細胞內。

                顏寧教授介紹稱,葡萄糖轉運蛋白GLUT1幾乎存在于人體的每一個細胞,是大腦、神經系統、肌肉等組織器官中最重要的葡萄糖轉運蛋白,對維持人體正常生理功能極為重要。這種轉運蛋白的功能完全缺失將致人死亡,功能部分缺失會導致大腦萎縮、智力低下、發育遲緩等疾病。

                同時,這種轉運蛋白在癌細胞的新陳代謝中也發揮著重要功能。癌細胞需要消耗超量葡萄糖才能維持其生長擴增,轉運蛋白GLUT1在細胞中顯著過量往往意味著有癌變發生。

                “因此,如能研究清楚GLUT1的組成、結果和工作機理,就有可能通過調控它實現葡萄糖轉運的人工干預。”顏寧教授說,這樣既可以增加正常細胞的葡萄糖供應,達到治療相關疾病的目的,又可以通過阻斷葡萄糖供應“餓死”癌細胞。

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