<form id="hdxdf"></form>

                <address id="hdxdf"><nobr id="hdxdf"><meter id="hdxdf"></meter></nobr></address>
                當前位置:首頁 > 資訊信息 > 新聞動態 > 詳細信息
                生物材料:8家上市公司沾邊2000億蛋糕
                來源: | 作者: | 發布時間:2013-9-26 10:27:58


                生物材料:8家上市公司沾邊2000億蛋糕


                如果說高分子材料的出現,為人類打開了材料世界的大門,那么生物醫用高分子材料的應用,則為人類揭開了生命世界神秘的面紗。

                  生物醫用高分子材料是一種特殊的功能高分子材料,通常用于對生物體進行診斷、治療以及替換或修復、合成或再生損傷組織和器官。

                  “雖然目前生物醫用器械材料規模比較小,但確實為消費者所需要。”醫藥企業管理協會秘書長于明德說道。

                  由于專業技術壁壘的限制,目前國內生物醫用材料專業生產企業并不多。隨著消費者對身體健康越來越為關注,市場對于生物醫用器械材料的需求正逐漸加大。

                  政策拉動市場需求

                  《新材料產業“十二五”發展規劃》明確提出,我們要加強生物醫用材料研究,提高材料生物相容性和化學穩定性,大力發展高性能、低成本生物醫用高端材料和產品,推動醫療器械基礎材料升級換代。“十二五”重大工程亦包含生物醫用材料專項工程。

                  科技部《醫療器械科技產業“十二五”專項規劃》中指出,醫療器械是國家科技進步和國民經濟現代化水平的重要標志,指明十二五期間醫療器械產業的重點產品方向、重點布局任務和政策保障措施,預期十二五期間拉動新增醫療器械產值2000億元。

                  醫療器械行業屬于高技術行業,涉及醫藥、機械、電子、塑料等多個行業,在我國屬于國家重點鼓勵發展的產業。《2013-2017年中國植入醫療器械行業產銷需求與投資預測分析報告》中顯示,2011年,我國已成為僅次于美國的世界第二大醫療器械市場。

                  “相比于高分子材料,生物醫用高分子材料能夠更好地和人體組織相融合,滿足生物力學要求,大幅降低材料物質對人體的傷害程度。”一名行業分析師告訴記者。

                  生物醫用高分子材料原材料主要包括聚乳酸、聚丁二酸丁二醇酯等脂類物質和鎳鈦支架、不銹鋼支架等物質材料。其中,脂類物質具有耐熱性、相容性、可降解性等性能,適用于膜類、垃圾袋等材料的生產。而物質材料則具有良好的壓縮性、拉伸強度、硬度等性能,常用于醫療行業的器械生產。

                  據理財周報材料科學實驗室數據統計,目前與生物材料相關上市公司共有8家,包括冠昊生物、迪康藥業等公司,其中冠昊生物和迪康藥業值得關注。

                  冠昊生物欲多樣化,無奈研發周期長

                  冠昊生物目前在產的產品主要為膜類產品,主要包括生物型硬腦(脊)膜補片(腦膜建)、胸普外科修補膜(體膜建)和無菌生物護創膜(得膜建)。其中腦膜建市場達40%以上,占總體主營業務收入的93.30%,是公司目前營業收入的主要來源。

                  過高的收入占比,使得公司潛藏著巨大的風險。一旦神經外科醫療市場發生重大波動導致需求萎縮,那么公司經營收入將深受影響。

                  據知情人士透露,目前公司正在加大對整形美容產品的研發。冠昊生物董事會辦公室相關人員告訴記者:“我們在上市時就提到未來往整形美容方向發展。現在很多醫院都設有專門整形美容科室,市場需求很大。”

                  與上述在售產品一樣,用于整形美容的組織補片也是以食用動物組織為原料,經過組織處理平臺得到的。最大的特點也是可直接入人體,誘導再生被動降解。婦科、整形美容等一系列產品的市場推廣也被市場認為公司未來的成長看點。

                  目前,生物型組織補片已完成臨床試驗,正在注冊報批。而骨誘導型可降解吸收生物活性骨修復材料及產品、透明質酸、人工角膜等新品正在產品設計或者動物實驗中。

                  “醫療事項進展、更新都是比較慢的,整個研發周期很長。公司除了研發產品周期,還要注冊、報批三四年時間的流程。從1997年公司開始投入研究到2005年創設第一個產品,中間經過了7~8年的研發周期。”上述相關人士告訴記者。

                  公司募投的重大項目再生型醫用植入器械國家工程實驗室建設已達到預定可使用狀態,營銷網絡擴建項目已完成84.32%的建設。雖然無菌生物護創膜高技術產業化工程建設項目僅完成27.11%的建設,但是項目達到預定可使用狀態時間為2013年。

                  公司產品的主要競爭對手是強生、貝朗醫療等國際知名的大型醫藥企業,其中強生在腦膜建市場中占有20%的份額。而在國內,雖然從事該類產品的上市公司只此一家,但是其他的企業也在發力新型產品的研發。

                  據悉,青島中皓生物的人工角膜已進入臨床,北京大學鄧宏魁教授已帶領干細胞再生醫學研究團隊完成表皮細胞逆轉“全能干細胞”實驗。

                  以學術推廣為核心,公司產品直接賣給正規三甲或者權威醫院,銷售對象都是醫生。

                  迪康藥業重組,專注生物材料藥品

                  迪康藥業的生物材料主要是可吸收醫用膜和可吸收骨折內固定螺釘。

                  可吸收醫用膜采用超高分子量可吸收聚-DL-乳酸材料,具有良好貼附性、柔韌性,能有效地隔離手術創面。而可吸收骨折內固定螺釘則采用超高分子量聚-DL-乳酸材料制成,可降解完全,彈性模量與松質骨近似。

                  迪康藥業除了生物材料,還主營藥品產業。由于藥品零售終端——和平連鎖業績不佳,迪康選擇退出藥品零售行業。目前正在進行重大資產重組,今年公司已將主業聚焦在藥品和醫療器械兩大產業上。

                  “生物材料是我們很早以前863項目轉化過來的,技術從剛開始到轉化過程已經經過很長時間,做得比較成熟。”迪康藥業董事會辦公室相關人員告訴記者。

                  相比冠昊生物,迪康藥業的銷售渠道還是走傳統路線,通過代理制,主要銷往一線城市。

                  在經過上半年的產業結構優化后,公司集中資源專注于消化系統用藥和生物醫學材料器械兩大產品群的生產和銷售。2013年6月24日董事會審議通過了使用自有資金購置土地約60畝左右,用于未來投資興建高新技術生物醫用材料研發生產基地

                  目前,公司已對所在地周邊的工業園區進行了綜合考察,并將結合政府掛牌出讓土地的實際情況選取適合的土地參與競買。



                苏宁彩票平台苏宁彩票主页苏宁彩票网站苏宁彩票官网苏宁彩票娱乐 u2146.com | www.8667r.com | 626810.com | www.25288w.com | www.60123q.com | 0166e.com | www.488700a.com | www.375736.com | zhcp15.com | www.737798.com | mmm5144.com | www.84303.com | www.769588.com | 30177788.com | www.37377i.com | yl66yl11.com | www.27363r.com | 00773o.com | www.9822msc.com | www.806721.com | 1077iii.com | www.68993273.com | 37111g.com | www.9b007.com | lll0055.com | www.4972ii.com | www.087b.com | 452.com | www.4078h.com | 7779.cc | www.jinsha8.net | www.335240.com | www.hg55768.com | www.60123p.com | chengbet.cc | www.3398755.com | 7726bbb.com | www.58665h.com | 123818.xxx | www.xpj386.com | www.354811.com | www.p35cc.com | www.897296.com | w32365.com | www.3668w.com | 3379zz.com | www.80767m.com | 28288rr.com | www.79670.com | g5429.com | www.bmw8044.com | 4340r.com | www.hg88676.com | mopayclub.com | www.xj7006.com | 4809y.com | www.mgm868003.com | z7454.com | www.c5c11.com | 6543sun.com | www.99mgm777.com | 0208ii.com | www.7920k.com | 3552s.com | www.393008.com | mm99977.com | www.6939l.com | 50067c.com | www.54400x.com | s47479.com | www.5522r.cc | www.hg2877.tv | www.658770.com | www.362858.com | www.35918o.com | www.pj3333.com | 3379ww.com | www.b35kk.com | 4647c.com | www.js02348.com | 8905f.com | www.989841.com | www.www8181msc.com | bowanwang.com | www.500994.com | 08159f.com | www.60886t.com | hg77703.com | www.2934l.com | www.929467.com | 66300vip10.com | www.68228p.com | c91234567.com | www.7249m.com | 5589h.com | www.qucp2.com | www.x22365.com | 22234066.com | www.47506b.com | hga088.rs | www.gei30.com | www.9068xx.com | 3936w.com | www.4078q.com | 9170110.com | www.9dwj.com | www.358888f.com | 54141100.com | www.55676v.com | 111122jj.com | www.505504.com | www.138585.com | 30688.com | www.hg57977.com | 80892ss.com | www.106507.com | www.bd2019d.com | 53166r.com | www.9356j.com | www.21365qq.com | 4869822.com | www.js89q.vip | 0747y.com | www.577062.com | www.jsc12315.com | 33rr8331.com | www.557595.com | www.d22255.com | 4995e.com | www.3890o.com | www.js40123.com | 2008rr.com | www.50026b.com | www.825909.com | 36502w.com | www.226467.com | www.292939.com | y337.com | www.22dwj.com | www.pj5747.com | ms407.com | www.3668n.com | www.bmw1195.com | 18775y.com | www.9478q.com | www.13090.com | 23599s.com | www.904867.com | www.csh365.com | 21052277.com | www.81678e.com | www.m.195668.com | www.3459x.com | 313.net | www.6832w.com | www.67843.com | 9679f.com | www.607316.com | www.455361.com | 3388xpj.com | www.095069.com | www.b3410.com | www.1869o.com | 3885.com | www.2373j.com | www.hg8297.com | tt1030.com | www.29277u.com | www.3691w.com | www.56520a.com | n888vv.com | www.607323.com | www.5886pp.com | www.9068ee.com | 4189111.com | www.178397.com | www.960620.com | www.hjdc2000.vip | 8037q.com | www.557031.com | www.30350p.com | www.76543s.com | 83138k.com | www.504833.com | www.18131.com | www.3643c.com | 77777ylg.com | 20188i.com | www.yh9877.com | www.vns3938.com | 65335Y.com | 1007811.com | www.hx2088.com | www.cn365j.com | www.bet365602.com | x88288.com | www.50080u.com | www.0967006.com | www.48tk.com | www.56733w.com | 5099bb.com | www.178075.com | www.09738.com | www.588112.com | am3144.com | 3678k.com | www.810702.com | www.792086.com | www.hg8373.com | 883399k.com | 3890o.com | www.303482.com | www.518pj.com | www.5099dd.com | www.56520p.com | 2jshhh.com | yd91.com | www.354911.com | www.wn816.com | www.c31d.vip | www.caipiao050.com | 8030c.com | lswjs189.com | www.88266e.com | www.5095x.com | www.40288o.com | www.220122a.com | 8790f.com | ctxcpyh.com | 500000439.com | www.914901.com | www.8081.am | www.y456x.com | www.333133b.com | k7742.com | 1775h.com | www.022613.com | www.2109l.com | www.8577d.cc | www.6668ylg.com | www.03688.com | bm1395.cc | vns00ff.com | 2677jjj.com | 59889z.com | www.933709.com | www.383444.com | www.185143.com | www.41610.com | www.yh03456.com | 99151g.com | 35222nn.com | 27878jj.com | www.50052v.com | www.hc5859.com | www.9989587.com | www.am8333.tw | www.16602g.com | www.1423guo.com | 611.cc | 2018mxc.com | lll444000.com | 8722wwww.com | 500000511.com | www.083016.com | www.965900.com | www.66376s.com | www.00765.com | www.5981l.com | www.759696.com | www.0wdgj.com | www.9068uu.com | 4812999.com | ylg11111.com | 11683355.com | 3788hh.com | 33432l.com | y5429.com | 3178uu.com | 5002r.com | 64111q.com | www.006150.com | www.576734.com | www.938751.com | www.00czj.com | www.50080x.com | www.660689.com | www.773570.com | www.v2662.com | www.88325s.com | www.w69096.com | www.19yh7.com | www.ff811.com | www.ra678.com | www.767.cc | www.49799.com | www.331393.com | www.282456.com | www.hg8855.com | www.09569b.com | www.h7788b.com | www.7893w54.com | www.8124v.com | www.yh-9.com | www.hg0125.com | tt3189.com | 2820i.com | 37570j.com | 1665h.com | www.ao799.com | www.5554dhy.com | www.8494b.com | www.365109i.com | www.zq.hk | www.76543k.com | www.32666u.com | www.cp08e.com | www.28249.com | www.718888.com | www.70suncity.org | www.5agcpw.com | www.4963s.com | www.biying930vip.com | www.38775uu.com | www.826019.com | www.7714k.com | www.36166z.com | www.igcp9.com | www.621410.com | www.178329.com | 6220dd.com | 67877l.com | 77005.com | 6363xx.com | 8905f.com | www.ylhg7878.com | www.35553999.com | www.2233suncity.com | www.16181t.com | www.44118t.com | www.6022888.com | www.2350d.com | www.811030.com | www.305922.com | 4997.com | 7508u.com | 7249v.com | feicai0357.com | www.939393.com | www.533998.com | www.cgcp.com | www.42842810.com | www.022js.cc | www.78949e.com | i3405.com | 1919394.com | 3301866.com | www.333177.com | www.10340.com | www.4996qj.com | www.13434e.com | www.gczj1.com | www.025728.com | 1114116.com | ii3405.com | p888123.com | www.y2205.com | www.c558.cc | www.14341434.com | www.kc66.com | jnh91.com | t61788.com | feicai0757.com | www.pj88111.com | www.5504w.com | www.0343.com | www.721560.com | syrbtz.com | 3775o.com | www.86611d.com | www.8349.com | www.amjs339.com | www.925073.com | 500000791.com | 4167d.com | 1389a.com | www.bbc228.com | www.48330q.com | www.805357.com | yabo6000.com | 00vv8332.com | www.408409.com | www.07679b.com | www.961205.com | 3807n.com | 8547j.com | www.698012.com | www.4196r.com | www.982pk.com | 4880p.com | df8kk.com | www.emc7677.com | www.2021a.com | www.hy6933.com | 22571333.com | 44488h.com | www.pj99111.com | www.h6630.com | www.326608.com | 1775s.com | www.long8139.com | www.hga66600.com | www.022jx.cc | 223639.com | am2015.cc | www.3362msc.com | www.222067.com | bet009900.com | 38850011.com | www.24suncity.com | www.806765.com | www.189370.com | 40033v.com | www.76543z.com | www.t3410.com | www.603294.com | 876q.com | www.8188zr.com | www.4102t.com | www.196072.com | j5069.com | www.pj2212.com | www.0004sc.com | 3009s.com | 3122jj.com | www.77699.com | www.ya989.com | 89777w.com | www.g2006.com | www.4546200.com | www.338785.com | uu01234.com | www.hg7211m.com | www.66332l.com | yataibet5.com | www.8520r.com | www.yh83.net | www.107186.com | 772061.com | www.55526e.com | www.c9335.com | 341qqq.com | www.27878gg.com | www.yt2019.com | i3144.com | www.ylhg4848.com | www.jj4625.com | jjs66.com | 8036w.com | www.58404c.com | www.153680.com | y45638.com | www.89599j.com | www.303482.com | 50099t.com | www.tt55826.com | www.549577.com | 029555.com | www.4972r.com | www.339281.com | df8z.com | www.js68111.com | 97297r.com | 9420d.com | www.087j.com | 78448.com | www.4625s.com | www.66653k.com | 00ff8332.com | www.k3322.com | www.904857.com | t444c.com | www.sb5503.com | wb8.com | www.68666m.com | www.984008.com | 2017dh.com | www.88570.com | www.hx6686.com | 3559a.com | www.7415s.com | 1434u.com | www.85770n.com | www.88266t.com | 0729a.com | www.caiba200.com | haianw.com | www.38200c.com | www.65707c.com | 7240t.com | www.caipiao88d.com | 87578003.xyz | www.hg558.com | www.3478m.cc | 8449zz.com | www.519345.com | dd2649.com | www.hg8237.com | www.503501.com | 20771166.com | www.57578j.com | 51133ccc.com | www.06386622.com | g2554.com | www.322113.com | www.214654.com | www.tm357.com | www.8499l.com | 463393.com | www.4809a.com | 31325t.com | www.55545b.com | 3434bbb.com | www.25288d.com | www.196203.com | www.6xinhao.com | www.fan73.com | feicai0512.com | www.xb8844.com | 4445365.com | www.4058cc.com | 1331u.com | www.cp505a.com | 0638.cn | www.331445.com | www.36166a.com | www.2078r.com | www.594911.com | www.hg9093.com | www.hc2788.com | 5647l.com | www.2875t.com | zhcp62.com | www.55228g.com | 58222nn.com | www.80767t.com | sp2088.com | www.bet365195.com | www.512988.com | www.yi432.com | lehu556.com | www.6ttz.com | www.jsh922.com | www.976291.com | www.wns8.com | www.725106.com | www.282xpj.com | www.599047.com | www.h067.com | www.302029.com | www.98am444.com | www.35918o.com | www.73077d.com | qg0707.com | www.226600r.com | 1294z.com | www.8850w6.com | 7508u.com | www.97994a.com | 3640pp.com | www.868339.com | blhvip77.com | www.9lbc.com | www.wns911.com | www.303865.com | www.yh00bet.com | am2984.com | www.77ok.com | 80567k.com | www.hg860033.com | 61324433.com | www.w725.com | www.87680u.com | abet384.com | www.770405.com | 66c51.com | www.32031i.com | 33318x.com | www.9356o.com | www.3333wnsr.com | www.022613.com | www.034044.com | 33599tt.com | www.77787yh.com | ib738.com | www.087wy.com | www.9068mm.com | 50067m.com | www.55545g.com | 3559jjjj.com | www.50732p.com | www.7amc.com | www.43131m.com | www.5m5.com | 7599.at | www.66653h.com | www.xhtd07.com | 690824.com | www.7415l.com | 1104.net | www.hm5522.com | www.hg5519.com | qqtheme.com | www.5551883.com | 883399x.com | www.517844.com | www.102666.com | 281555.com | www.54400h.com | www.42424688.com | 3009k.com | www.56011i.com | 3844n.com | www.022613.com | www.sscb11.cc | 61327755.com | www.703890.com | www.37728.com | 4136f.com | www.126ll.com | www.hga8383.com | js567567.com | www.81678w.com | www.00829m.com | 19927.com | www.hg99976.com | www.bet3651014.com | mm3189.com | www.4833045.com | www.36360.cc | 1495f9.com | www.fg500.com | www.yinhecc99.com | hg999333n.com | www.959595.org | www.dh03035.com | 4116a.com | www.7714b.com | www.sb276.com | 9506z.com | www.66368.com | www.wnsr7788.cc | xpj5009.com | www.ch8567.com | www.9101901.com | 86611j.com | www.511622.com | www.89599d.com | feicai0754.com | 666365.com | www.3775l.com | www.4107o.com | 00773z.com | www.33qxc.com | www.g7817.vip | nyty08.com | 3333904.com | www.68365l.com | www.9976799.com | 47749h.com | www.w593.com | www.8828fh.com | t47479.com | 272o.net | www.77996b.com | www.28758c.com | 2138001.com | www.73166a.com | www.i63568.com | www.mmtx22.com | 444000ff.com | www.398244.com | www.995223.com | www.hg78088.com | 3778802.com | www.602430.com | www.2208598.com | www.0000wnsr.com | baliren137.com | www.648689.com | www.2544g6.com | www.06bwin.com | 56728i.com | www.326675.com | www.h36599.com | www.2846hh.com | 6261.com | 7945tt.com | www.33112s.com | www.007ggb01.com | www.033033e.com | 86811ll.com | www.564880.com | www.380870.com | www.166249.com | 22332007.com | 4997l.com | www.22ckb.com | www.v88136.com | www.654bet.com | 7599y.com | 336v.com | www.1888ac.com | www.t69096.com | www.365815v.com | 4288k.com | 5003com | www.008hy.cc | www.313965.com | www.272875.com | 00443015.com | c89fh55.com | www.594611.com | www.x22678.com | www.174666.com | 7775144.com | aa4119.com | 6150b.com | www.ya618.com | www.792050.com | www.11119dz.com | feicai010.com | yl6944.com | 22299jj.com | www.22yfa.com | www.669112.com | www.35138.com | 4546vip9.com | ddd67890.com | 2355.com | www.542770.com | www.4323u.com | www.89599x.com | www.pj3678.com | 2381xx.com | 3678m.com | 518cp.com | www.578860.com | www.904028.com | www.04567k.com | www.323567.com | 1077ddd.com | 0073.com | hg168o.com | www.606530.com | www.71399g.com | www.2000c.cc | www.102666.com | www.41414688.com | g35151.com | 3568rr.com | jixiang5.com | www.43131g.com | www.fyyy8.com | www.ykylc00.com | www.hg8jj.com | www.88597.com | www.370766.com | www.3668t.com | www.gx58qp.com | www.vns6604.com | www.904044.com | www.v0020.com | 3189ii.com | 30688h.com | 4444.ag | 131ggg.net | www.318187.com | www.qilc7.com | www.yh9877.com | www.7036d.com | www.55545b.com | www.6677104.com | www.35359193.com | 1634u.com | pj7686.com | 4488ppp.com | 3659008.vip | 1479.cc | 86811j.com | www.372779.com | www.hy6936.com | www.79520b.com | www.1434s.com | www.r80288.com | www.27363t.com | www.015kj.com | www.h2678.com | www.99955545.com | www.xjs8893.com | 2546h.com | JS1388f.com | 56400.com | 55323u.com | 12274444.com | aobo19.com | blr9944.com | 6601wz.com | 2095979.com | 2820x.com | 4066yy.com | www.50080i.com | www.267051.com | www.591032.com | www.811597.com | www.c1396.com | www.qml7.com | www.99ckb.com | www.5095i.com | www.62500.cc | www.02500w.com | www.50052c.com | www.71233l.com | www.99638n.com | www.6653g.com | www.02088.com | www.4923w.com | www.js69z.cc | www.vip3303.net | www.2221103.com | www.7256.com | www.7714g.com | www.dy826.com | www.288963.com | www.6653k.com | www.78700k.com | www.50026w.com | www.89929.cc | www.2109b.com | www.66ffs.com | www.c5839.com | www.955494.com | www.885345.com | www.730265.com | www.504733.com | www.277474.com | www.54400u.com | 73055.cc | 2698c.com | o08199.com | 44775156.com | 3473j.com | 888991188.com | 3668yh.com | 923960.com | 881381.com | www.pj6651.com | www.h32126.cc | www.46768.com | www.7335y.com | www.8313s.com | www.2000e.cc | www.81608a.com | www.99788h.com | www.3126a.com | www.854242.com | www.306061.com | t000c.com | 28288zz.com | 2566h1.com | 496ll.com | 518cp6.com | www.wan6668888.com | www.vns799.com | www.5966lll.com | www.8473a.com | www.664456.com | www.15.net | www.08gcw.com | www.390006.com | 3245777.com | 80850g.com | 759hd.com | 28288aa.com | www.1869z.com | www.d30226.com | www.343888.com | www.88.net | www.93gj07.com | www.878.me | www.109307.com | 2127kk.com | yuhe.ooo | 8290p.com | www.7025l.com | www.jbb2017.com | www.663558.com | www.7714f.com | www.770960.com | 74395555.com | 0621.com | 88am.cc | www.m4737.com | www.0999msc.com | www.42070017.com | www.38396.com | www.230967.com | 28824z.com | 9506j.com | www.laok000.com | www.pj2299.com | www.783644.com | www.52303c.com | www.401270.com | 8890850.com | 3662b.com | www.tqdc04.com | www.848883.com | www.js68678.com | www.3479s.com | 56987zz.com | 777hg999.com | 014458.com | www.hg139e.com | www.45598v.com | www.08588q.com | www.65707e.com | w88u18.com | qq2649.com | www.36607a.com | www.40288.com | www.kc67.com | 4638877.com | s86226.com | www.283804.com | www.caipiao88a.com | www.99638p.com | www.xinyc3.com | qjdy001.com | 1591ccc.com | www.ra678.com | www.89777b.com | www.335294.com | pj1007.com | 777hg555.com | www.e7457.com | www.502206.com | www.258031.com | 11422e.com | 22883c.com | www.dzcp7777.com | www.26163u.com | www.43131k.com | 3679pp.com | www.pu15.com | www.3066jj.com | www.csgc8.com | 3656aa.com | 500000952.com | www.190089.com | www.hg3005.com | www.55228a.com | 3405xxx.com | www.4938j.com | www.63606i.com | www.701546.com | drcp111.com | www.agg8887.com | www.8313g.com | www.gocp1.com | 15a21.net | 55betbet365.com | www.5b5b.com | www.1035v.com | wxylc98953.com | yh888i.com | www.cp009x.com | www.77qxc.com | 77201.com | 88535f.com | www.04567q.com | www.ybao9.com | 7335g.com | www.514234.com | www.8800ra8.com | www.818797.com | 1813l.com | www.m27229.com | www.9187z.com | www.78700a.com | 9694s.com | www.am1155.com | www.26299p.com | jidu3.com | www.6666bmw.com | www.69989b.com | www.335243.com | 5003z.com | www.291234.com | www.37022.cc | 2008kk.com | www.hg6262.co | www.x63568.com | 50067a.com | 31894000.com | www.5146z3.com | www.602630.com | 30688z.com | www.6718.cc | www.2408d.com | 883399s.com | www.902505.com | www.99677p.com | 5802uu.com | www.hg002222.com | www.ykylc05.com | 7003pp.com | www.hg5857.com | www.q94600.com | pujingzaixianyule.com | xcdc688.com | www.115527u.com | www.55228i.com | 9030h.com | www.00778y.com | www.99638i.com | 83377l.com | www.00778f.com | 35yy.vip | 67888.am | www.ba503.com | 9905.com | www.hg8988.com | www.222335.com | 97799h.com | www.alpk33.com | www.9646u.com | 2222bj.com | www.pj1422.com | www.8816f.com | 2222k04.com | www.243888.com | www.729987.com | 22ff8332.com | www.694942.com | 0885r.com | www.hmgj05.com | www.35898a.com | 20771199.com | www.6666zs.com | www.hcjt9.com | 1294x.com | www.dzj0770.com | 118888j.com | www.hg430.com | www.2222bj.com | bwinyyy.com | www.999345.com | www.578393.com | ff555e.com | www.hg82678.com | 7792t.com | www.026555.com | www.djcp009.com | hgyz33.com | www.js89f.vip | 53206600.com | www.3844d.com | www.665478.com | 6220q.com | www.x33678.com | 99589e.net | www.fc841.com | www.hcw332.com | www.yl12007.com | www.61655g.com | 4025e.com | www.4996sh.com | yh3434.com | www.550515.com |