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                Oncotarget:揭示膠質母細胞瘤對藥物療法耐受的分子機制
                來源: | 作者: | 發布時間:2013-9-25 9:26:28


                     近日,來自加利福尼亞大學的研究人員通過研究揭示了特定膠質母細胞瘤對藥物療法產生耐藥的機制,膠質母細胞瘤是一種致死性的腦癌,研究者表示,引發膠質母細胞瘤耐藥的并不是腫瘤的DNA在作祟,而是其表觀遺傳標記在搗鬼,這項研究刊登于國際雜志Oncotarget上。

                研究者Clark Chen博士表示,科學家們越來越熱衷于通過對癌細胞的DNA進行測序來開發癌癥療法,我們的研究闡明,膠質母細胞瘤對藥物的敏感性并不僅僅收到其DNA序列本身內容的影響,而且還受到DNA序列的組裝排布的影響。

                這項研究中,研究人員利用一種名為比較基因特性分析的技術對來自約900名膠質母細胞瘤病人機體的組織進行了遺傳特性的分析,這種技術可以幫助研究人員區分膠質母細胞瘤的特殊細胞過程是出于開啟還是關閉狀態;研究顯示,所有的膠質母細胞瘤并不相同,基于誘導腫瘤生長的癌細胞的細胞過程的類型不同,研究人員就可以對膠質母細胞瘤進行區分。

                研究者發現,其中一種癌細胞細胞過程涉及表皮生長因子受體(EGFR);研究顯示,EGFR信號通路在一些膠質母細胞瘤亞型腫瘤中處于抑制狀態,更為重要的是,EGFR的關閉可以用以揭示編碼EGFR基因的DNA在癌細胞中被組裝的分子機制,這種調節方式就被稱為表觀遺傳學調節,因為在這些膠質母細胞瘤中EGFR處于關閉狀態,因此其就會對一些抑制EGFR信號的藥物變得不敏感。

                最后研究者Zachary J. Taich說道,我們的研究表明,針對腦癌患者合適療法的選擇或許會為患者提供一種更好的遺傳學分析以及來自癌細胞的表觀遺傳學信息,這就為開發治療膠質母細胞瘤的新型療法提供了很好的研究思路和基礎。


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